A closer look at the Qure Study

The Qure study was one of the largest randomized treatment trials for patients suffering from a postinfectious fatigue syndrome. Although the study focused on Q-fever, a disease caused by the bacterium ‘Coxiella burnetii’, it might have implications for patients suffering from long-lasting fatigue after COVID-19 or other infections. Dutch physician Mark Vink has written a …

A summary of our paper on exercise therapy and bias caused by lack of blinding

On 25 November a new paper was published by David Tuller (University of California, Berkeley), Caroline Struthers (Oxford University) and myself (Michiel Tack, a long-time ME/CFS patient). The paper is about exercise therapy for chronic fatigue syndrome and bias due to lack of blinding. This blog post provides a short summary. The paper was published …

Turning a blind eye to blinding

Blinding, sometimes called masking, is the process of keeping key persons involved in the conduct of a clinical trial unaware of group assignment. In a typical randomized controlled trial, neither patients nor therapists know who is getting the active treatment and who is getting a placebo pill. The idea behind this is simple: knowledge of …

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